ChemicalBook >> CAS DataBase List >>4'-Hydroxyacetophenone


Chemical Name:
Molecular Formula:
Molecular Weight:
MOL File:
MSDS File:

4'-Hydroxyacetophenone Properties

Melting point 132-135 °C(lit.)
Boiling point 147-148 °C3 mm Hg(lit.)
Density 1.109
refractive index 1.5577 (estimate)
Flash point 166 °C
storage temp. Store below +30°C.
solubility methanol: 0.1 g/mL, clear
form Crystalline Powder
pka 8.05(at 25℃)
color Almost white to beige
Specific Gravity 1.109
Water Solubility 10 g/L (22 ºC)
JECFA Number 2040
BRN 774355
CAS DataBase Reference 99-93-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 4-HYDROXYACETOPHENONE
EWG's Food Scores 1
NIST Chemistry Reference Acetophenone, 4'-hydroxy-(99-93-4)
EPA Substance Registry System 4-Hydroxyacetophenone (99-93-4)


Risk and Safety Statements

Signal word  Warning
Hazard statements  H302-H315-H301-H335-H319-H412
Precautionary statements  P261-P280a-P301+P310a-P405-P501a-P305+P351+P338-P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-22
Safety Statements  26-36/37-37/39-24/25-22-36
WGK Germany  3
RTECS  PC4959775
Hazard Note  Irritant
HS Code  29145000
NFPA 704
2 0

4'-Hydroxyacetophenone price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1971 Acetaminophen Impurity E Pharmaceutical Secondary Standard; Certified Reference Material 99-93-4 100MG $388 2022-05-15 Buy
Sigma-Aldrich PHL80232 4′-Hydroxyacetophenone phyproof? Reference Substance 99-93-4 100MG $231 2022-05-15 Buy
Sigma-Aldrich BP770 4′-Hydroxyacetophenone British Pharmacopoeia (BP) Reference Standard 99-93-4 25MG $228 2022-05-15 Buy
Sigma-Aldrich 8.04311 4′-Hydroxyacetophenone for synthesis 99-93-4 100 g $53.1 2022-05-15 Buy
Sigma-Aldrich 8.04311 4′-Hydroxyacetophenone for synthesis 99-93-4 250 g $97.8 2022-05-15 Buy
Product number Packaging Price Buy
PHR1971 100MG $388 Buy
PHL80232 100MG $231 Buy
BP770 25MG $228 Buy
8.04311 100 g $53.1 Buy
8.04311 250 g $97.8 Buy

4'-Hydroxyacetophenone Chemical Properties,Uses,Production

Chemical Properties

White to beige powder; sweet, hawthorn, balsam, mimosa aroma

Chemical Properties

almost white to beige crystalline powder


Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort.


4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.


4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.


p-Hydroxyacetophenone is widely used in medicine, cosmetics and industrial fields. It is a natural plant extract, which naturally exists in the stems and leaves of the Compositae plant, Artemisia annua, the roots of plants such as Artemisia annua, Rhododendron, and Panax ginseng. It has a good effect on yellow eyes caused by diseases such as hepatitis, and also has a good auxiliary effect on yellow eyes caused by various reasons. Due to its weak molecular activity, high temperature resistance, melting point of 95-97 °C and boiling point of 296 °C, it is widely used in various liquid pharmaceuticals and can prolong the shelf life of other active ingredients under high temperature conditions. It has no harm to human skin and is the safest high-temperature auxiliary active stabilizer in the pharmaceutical industry.


Preparation by Fries rearrangement of phenyl acetate with Lewis acids
aluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.


ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.

Aroma threshold values

Floral type, medium strength odor; recommend smelling in a 10.00% solution or less.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 5829, 1991 DOI: 10.1016/S0040-4039(00)93567-6

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Purification Methods

Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]

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View Lastest Price from 4'-Hydroxyacetophenone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-06-21 4'-Hydroxyacetophenone
US $5.00 / kg 10kg 99% 20tons Hebei Linwo New Material Technology Co., LTD
2022-03-23 4'-Hydroxyacetophenone
US $1.00 / kg 1kg 99% 1ton Henan Guange Biotechnology Co. LTD
2022-03-17 4'-Hydroxyacetophenone
US $100.00 / bag 1bag 99 500 Shanxi Naipu Import and Export Co.,Ltd
1-(4-hydroxyphenyl)-ethanon 4’-hydroxy-acetophenon Hydroxyacetophenone, para HYDROXYACETOPHENONE-4 HYDROXYBENZOPHENONE-4 AKOS BBS-00003226 4-ACETOPHENOL 4-BENZOYLPHENOL 4'-HYDROXYACETOPHENONE 4-HYDROXYPHENYL METHYL KETONE 1-(4-HYDROXY-PHENYL)-ETHANONE 4'-Hydroxyacetophenone 4-Acetylphenol 4-HydraxyAcetophenone 4-HYDROXY ACETOPHENONE (p-HYDROXY ACETOPHENONE) 4'-Hydroxyacetophenone,99% PARA-METHYLKETOPHENOL PARA-ACETYLPHENOL Acetophenone,4'-hydroxy- D-Hydroxyacetophehone 4''-HYDROXYACETOPHENONESALBUTAMOL 4'-Hydroxyacetophenone 4'-Hydroxyacetophenone,98% Methyl p-hydroxyphenyl ketone methyl-p-hydroxyphenylketone Phenol, p-acetyl- p-hydroxy-acetophenon p-Hydroxyphenyl methyl ketone p-hydroxyphenylmethylketone p-Oxyacetophenone USAF kf-15 usafkf-15 P-BENZOYLPHENOL P-ACETOPHENOL 1-(4-hydroxyphenyl)-1-ethanone HYDROXYACETOPHENONE, P- (RG) 4'-Hydroxyacetophene 4'-Hydroxyacetopheno Methyl 4-Hydroxyphenyl Ketone NSC 3698 p-Hydoxyacetophenone 4-Acetophenol 4-Acetylphenol 4-Hydroxyphenyl Methyl Ketone 4'-HYDROXYACETOPHENONE FOR SYNTHESIS Acetophenone, 4'-hydroxy- (6CI,8CI) Acetophenone, p-hydroxy- (3CI) ParacetaMol IMpurity E 1-(4-Hydroxyphenyl)ethan-1-one, 4-Acetylphenol The hydroxy acetophenone 4'-Hydroxyacetophenone> 1-(4-Hydroxyphenyl)ethanone (4-Hydr 4'-Hydroxyacetophenone fandachem Paracetamol(Acetaminophen) EP Impurity E P-Hydroxy acetophenone -99% Factory supply 4'-Hydroxyacetophenone CAS 99-93-4 high quality Acetaminophen impurities1459 Acetaminophen EP Impurity E p-Hydroxy acetophenone, 98%+ Hydroxyce Tophenone Acetaminophen Impurity E
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