ChemicalBook >> CAS DataBase List >>Esomeprazole sodium

Esomeprazole sodium

CAS No.
161796-78-7
Chemical Name:
Esomeprazole sodium
Synonyms
Nexium sodium;Esomeprazole Na;EsoMeprazole sod;ESOMEPRAZOLE SODIUM;Esomeprazoleandsalts;(S)-OMeprazole sodiuM;Esomeprazole Sodium D3;Esomeprazole sodium CRS;(S)-Omeprazole Sodium Salt;Esomeprazole Impurities523
CBNumber:
CB7123722
Molecular Formula:
C34H36MgN6O6S2
Molecular Weight:
713.12
MOL File:
161796-78-7.mol

Esomeprazole sodium Properties

Melting point 156 °C (approx)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
Stability Hygroscopic
FDA UNII L2C9GWQ43H

Esomeprazole sodium price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC O635011 (S)-OmeprazoleSodiumSalt 161796-78-7 10mg $270 2021-12-16 Buy
TRC O635011 (S)-OmeprazoleSodiumSalt 161796-78-7 100mg $1420 2021-12-16 Buy
Matrix Scientific 092962 Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide 95+% 161796-78-7 1g $1647 2021-12-16 Buy
American Custom Chemicals Corporation API0005028 ESOMEPRAZOLE SODIUM 95.00% 161796-78-7 1G $1661.47 2021-12-16 Buy
SynQuest Laboratories 8H62-1-00 5-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt 161796-78-7 100 g $232 2021-12-16 Buy
Product number Packaging Price Buy
O635011 10mg $270 Buy
O635011 100mg $1420 Buy
092962 1g $1647 Buy
API0005028 1G $1661.47 Buy
8H62-1-00 100 g $232 Buy

Esomeprazole sodium Chemical Properties,Uses,Production

Anti-ulcer drug

Esomeprazole Sodium is the sodium salt form of esomeprazole. It is a commonly used anti-ulcer drug, which was first successfully developed by the Swedish company Astra Zeneca first. It belongs to a proton pump inhibitor. The proton pump inhibitor is the primary choice for treating peptic ulcer, gastro-oesophageal reflux disease and other acid-related diseases. Currently commonly clinically used PPI include five kinds: omeprazole, lansoprazole, rabeprazole, pantoprazole and esomeprazole. As the first PPI, the omeprazole’s drug efficacy in treating acid-related diseases has been widely recognized. Esomeprazole is the S-isomer of omeprazole, which can reduce gastric acid secretion by specific targeting mechanism. It is the specific inhibitor for the proton pump inhibitor in the parietal cell. Owing to the metabolic advantage of esomeprazole, it has a higher bioavailability and more consistent pharmacokinetics than its counterpart, omeprazole sodium, increasing the drug that reaches the proton pump. Its role of gastric acid control is much better than other proton pumps inhibitors such as lansoprazole, pantoprazole, and rabeprazole.
In animal experiments, this product has a dose-dependent inhibition of the Na+/K+ ATP enzyme activity of the isolated rabbit parietal cells with an IC50 of 60 μmol/L. Its efficacy is greater than omeprazole (IC50: 100 μmol/L). Meanwhile, esomeprazole sodium can inhibit histamine-induced 14C aminopyrine accumulation in isolated human parietal cells. Its effect intensity is 2 times of omeprazole.
Intravenous or intestinal injections of esomeprazole sodium to the experimental fistulization rats can inhibit gastric acid secretion caused by histamine with the ED50 were 0.24 and 0.43 mg/kg, respectively. For omeprazole with the same way of injection, the ED50 is 0.30 and 0.68 mg/kg, respectively.
Using esomeprazole sodium in the gut of pylorus ligated rats enteral use esomeprazole sodium can reduce the basic amount of secreted gastric acid with potency three times larger than that of omeprazole. The drug can prevent and treat the stress or alcohol-induced gastric damage of experimental rats, also can prevent and treat the gastric lesions induced by acetic acid and indomethacin. Its ED50 values ??were 1.6 and 5.5 mg/kg, respectively. From the above results, the efficacy on ulcers of esomeprazole is greater than that of omeprazole.
In addition, experimental data has also shown that when esomeprazole sodium is combined with penicillin and clarithromycin, it can be effectively applied for treating the duodenal and peptic ulcers caused by H. pylori infection.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Pharmacokinetics

After intravenous injection of 5mg/kg 14C-labeled esomeprazole sodium into the SD rats, the half-life of the plasma concentration for female rats is 7.3 h, and 17.4 h for female rats. It can be rapidly absorbed through oral administration. Its plasma level exhibits bimodal peaks at 1h and 4h after taking drugs, respectively. The biliary drainage experiments of rats found that the absorption process after administration have a duration of 24 h or more. The order of concentration of drug in different organs is as below: liver> kidney> lung> blood> fat. For oral administration, the drug is mainly excreted through feces. The pharmacokinetics curve of esomeprazole is linear. When increasing the dose, the AUCs and cmax concurrently increase, while tmax, CL and half-life still keep constant.
Esomeprazole sodium has a relative low toxicity. LD50 of rat through oral administration is greater than 5g/kg. For intraperitoneal administration, the LD50 is also over 2.5g/kg. Canine can take a dose 10mg/kg dose per day continuously for 28 d with no obvious abnormalities observed. For rats subjected to continuous medication for 13 weeks at a dose of 80 mg/kg, all the physiological parameters were not changed. The toxicity amount is over 320 mg/kg. In general pharmacological experiments, this product has a extremely small effect on the cardiovascular and autonomic nervous system. It only has a slight effect on the central nervous system at high dosage.

Indications

For the treatment of Gastroesophageal reflux disease (GERD)-erosive reflux esophagitis.
Used for long-term maintenance therapy for cured esophagitis patients to prevent recurrence.
Symptomatic control of gastroesophageal reflux disease (GERD).
Heartburn and combined with other appropriate antimicrobial therapy for totally eradication of Helicobacter pylori-induced gastric and duodenal ulcers.

Drug Interactions

Esomeprazole sodium can reduce the absorption of ketoconazole and itraconazole. When combined with the product, we should reduce the dosages of drugs metabolized by the enzyme CYP2C19 such as diazepam, citalopram, imipramine, clomipramine and phenytoin. When combined with the product or stop using this product, we should also monitor the plasma concentrations of phenytoin.
No interaction between the product and the amoxicillin, quinidine or warfarin was observed. No need for dose adjustment when combined with clarithromycin.
There is not too much clinical information of excess taking drug. But a single dose of 80 mg of this product has no adverse reactions. This product has no special antidote.

Dosage

This product should be swallowed with water, and cannot be taken after chewing or crushing.
Adults: For treatment of erosive reflux esophagitis: 40mg per day. Continuously take for 4 to 8 weeks. For long-term maintenance therapy and prevention of relapse for cured esophagitis patients, the recommended dosage is 20mg per day. For symptomatic CORD without suffering from esophagitis: 20mg per day. Take it for 4 weeks (If fail to control the symptoms, the patient should subject to further observation). Once symptoms have been got controlled, then the can use the dosage as needed for controlling the future symptom, such as 20 mg per day. For the triple associated therapy used for Helicobacter pylori eradication, prevention and cure of duodenal ulcer caused by Helicobacter pylori, and also Helicobacter pylori-induced recurrence of peptic ulcer: 20mg, amoxicillin 1g and clarithromycin 500mg, 2 times a day, medication for 7d.
For elderly patients or patients of mild or moderate hepatic impairment, there is no need for dosage adjustment. It should be concerned that the maximal dosage should not exceed 20 mg for patients with severely impaired liver function.
Children and lactating women are not recommended for taking this drug.

Side effects

Common adverse reactions (incidence of 1% to 10%) include headache, abdominal pain, diarrhea, gastrointestinal disorders, flatulence, nausea and vomiting, and constipation. Other adverse reactions (incidence of 0.1% to 1%) include dermatitis, itching, hives, dizziness, and dry mouth.

Precautions

Patients who are allergic to Benzimidazole-class drug are not allowed to use esomeprazole sodium. Patients of rare hereditary fructose intolerance, glucose-galactose absorption dysfunction, sucrase-isomaltase deficiency, and also lactation women are not allowed to use this drug.
Patients who have severe impaired liver or renal function, long-term treatment, malignant warning before using, and pregnant women should use with caution. When any warning symptoms (such as significant weight loss, recurrent vomiting, dysphagia, vomiting blood or black stools) happens, patients should be checked to exclude the possibility of malignant disorders (such as cancer) due to that treatment can worsen the symptoms and delay diagnosis. Long-term user should be regularly monitored.

Uses

Treatment of peptic ulcer, gastroesophageal reflux disease and other acid-related diseases.

Chemical Properties

Beige Solid

Uses

(S)-Omeprazole is the (S)-enantiomer of Omeprazole (O635000) a gastric proton-pump inhibitor. (S)-Omeprazole is more potent that its (R)-enantiomer and is used in the treatment of gastroesophageal ref lux disease as well as gastrointestinal ulcers associated with Crohn's disease.

Uses

(S)-Omeprazole is the (S)-enantiomer of Omeprazole (O635000) a gastric proton-pump inhibitor. (S)-Omeprazole is more potent that its (R)-enantiomer and is used in the treatment of gastroesophageal reflux disease as well as gastrointestinal ulcers associated with Crohn''s disease.

brand name

Nexium (AstraZeneca).

Esomeprazole sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 417)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangsu Zhongbang Pharmaceutical Co., Ltd.
025-87151996 zbsales@chinaredsun.com CHINA 32 55
HAINAN POLY PHARMCEUTICAL CO. LTD
+86-86-0571-89385087 +8613616530509 ff@hnpoly.com China 117 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 info@dakenchem.com China 16666 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1815 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 info@tianfuchem.com China 22021 55
Shanghai Time Chemicals CO., Ltd.
021-57951555 +8618017249410 jack.li@time-chemicals.com China 1809 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 fandachem@gmail.com China 9382 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
21-51619050 ivan@atkchemical.com China 26815 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29959 58

View Lastest Price from Esomeprazole sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-06-02 Esomeprazole sodium
161796-78-7
US $0.00-0.00 / kg 0.1KG 99.0% 300 tons Shaanxi Dideu Medichem Co. Ltd
2022-02-25 Esomeprazole sodium
161796-78-7
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2022-02-25 Esomeprazole sodium
161796-78-7
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
(S)-OMeprazole sodiuM 1H-BENZIMIDAZOLE, 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL]SULFINYL]-, SODIUM SALT ESOMEPRAZOLE SODIUM Esomeprazoleandsalts 5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl-1H-benzimidazole sodium salt SodiuM (S)-6-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfinyl)benzo[d]iMidazol-1-ide odiuM (R)-6-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfinyl)benzo[d]iMidazol-1-ide EsoMeprazole sod Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-i (S)-Omeprazole Sodium Salt 1H-BenziMidazole,6-Methoxy-2-[(S)-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfinyl]-, sodiuMsalt (1:1) Esomeprazole sodium 5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl-1H-benzimidazole sodium salt Esomeprazole sodium impurity Calcium Folinate Leucovorin Calcium 5-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol- 5-METHOXY-2-((S)-((4-METHOXY-3,5-DIMETHY L-2-PYRIDIYL)METHYL)SULFINL)-1H-BENZIMID AZOLE-1-YL)SODIUM Esomeprazole Na 5-methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]benzimidazol-3-ide 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methane]sulfinyl}-1-sodio-1H-1,3-benzodiazole sodium (S)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide sodium (R)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide Esomeprazole sodium CRS sodium 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methane]sulfinyl}-1H-1,3-benzodiazol-1-ide Esomeprazole sodium fandachem Nexium sodium Esomeprazole sodium USP/EP/BP 6-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt Esomeprazole sodium (S-Omeprazole sodium) Esomeprazole Impurities523 Esomeprazole Impurities522 Esomeprazole sodiumQ: What is Esomeprazole sodium Q: What is the CAS Number of Esomeprazole sodium Q: What is the storage condition of Esomeprazole sodium Q: What are the applications of Esomeprazole sodium Esomeprazole sodium (Y0002075) Esomeprazole Sodium D3 USDMF & CEP grade Esomeprazole Sodium 161796-78-7 C17H20N3NaO3S C17H18N3O3NaS 3674 Inhibitors zjh ACTIVE PHARMACEUTICAL INGREDIENTS
<s id='NwjO'><cite></cite></s><tt id='NhihCCPc'><u></u></tt><address id='oxtYcSGY'><i></i></address><basefont id='nmSEZM'><option></option></basefont>
<nobr id='qXhO'><basefont></basefont></nobr><comment id='RSuUiho'><label></label></comment>
    <listing id='gbAdGHWS'><em></em></listing><l id='fCvS'><dfn></dfn></l>
        <sup id='nqRD'><dfn></dfn></sup><u id='Wk'><legend></legend></u>
        <strong id='RPefk'><blockquote></blockquote></strong>
        <strong id='sGyucuHo'><thead></thead></strong><bdo id='oDwVbdey'><listing></listing></bdo>