ChemicalBook >> CAS DataBase List >>2,2'-Bipyridine


Chemical Name:
Molecular Formula:
Molecular Weight:
MOL File:
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2,2'-Bipyridine Properties

Melting point 70-73 °C(lit.)
Boiling point 273 °C(lit.)
Density 1.1668 (rough estimate)
refractive index 1.4820 (estimate)
Flash point 121 °C
storage temp. room temp
solubility 5.5g/l
form Crystalline Powder
pka pK1:-0.52(+2);pK2:4.352(+1) (20°C)
color White to almost white
Odor Characteristic odour
PH 7.5 (5g/l, H2O, 25℃)
Water Solubility 5.5 g/L 22 ºC
Merck 14,3347
BRN 113089
Stability Stable. Incompatible with strong oxidizing agents, most common metals. May be light sensitive.
CAS DataBase Reference 366-18-7(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference 2,2'-Bipyridine(366-18-7)
EPA Substance Registry System 2,2'-Bipyridine (366-18-7)


Risk and Safety Statements

Signal word  Danger
Hazard statements  H301-H315-H319-H341-H301+H311-H312
Precautionary statements  P280-P301+P310-P312-P301+P310+P330-P302+P352+P312-P280h-P301+P310a-P312a-P321-P501a-P201-P202-P264-P270-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P308+P313-P405-P501
Hazard Codes  T,Xi
Risk Statements  25-36/37/38-20/21-23/24/25-21
Safety Statements  36/37-45-36/37/39-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  DW1750000
Hazard Note  Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29333999
Toxicity LD50 i.p. in mice: 200 mg/kg (Grady)

2,2'-Bipyridine price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 798533 2,2′-Bipyridyl anhydrous, free-flowing, Redi-Dri , ReagentPlus , 99% 366-18-7 100g $76 2022-05-15 Buy
Sigma-Aldrich 798533 2,2′-Bipyridyl anhydrous, free-flowing, Redi-Dri , ReagentPlus , 99% 366-18-7 50g $151 2022-05-15 Buy
Sigma-Aldrich 1.03098 2,2′-Bipyridine GR for analysis (reagent for iron(II) and molybdenum) ACS 366-18-7 5 g $55.1 2022-05-15 Buy
Sigma-Aldrich 1.03098 2,2′-Bipyridine GR for analysis (reagent for iron(II) and molybdenum) ACS 366-18-7 25 g $185 2022-05-15 Buy
TCI Chemical B0468 2,2'-Bipyridyl >99.0%(T) 366-18-7 25g $48 2022-04-27 Buy
Product number Packaging Price Buy
798533 100g $76 Buy
798533 50g $151 Buy
1.03098 5 g $55.1 Buy
1.03098 25 g $185 Buy
B0468 25g $48 Buy

2,2'-Bipyridine Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder


2,2'-bipyridine acts as a bidentate chelating ligand which form complexes with transition metal ions and shows antifungal, antibacterial and antiviral activity. It is used for the colorimetric determination of iron as well as oxidation reduction indicators to confirm the presence of ferrous ion in soils. It forms complexes with ruthenium and platinum, exhibit intense luminescence, which may have practical applications. Copper(I) bipyridine complexes involved in the oxidation of alcohols under aerobic conditions.


As a reagent for the determination of iron.


A high-affinity chelator of iron


ChEBI: A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.

Synthesis Reference(s)

Journal of the American Chemical Society, 100, p. 5567, 1978 DOI: 10.1021/ja00485a053
Synthesis, p. 564, 1986 DOI: 10.1055/s-1986-31705

General Description

2,2′-Bipyridyl, is a symmetrical bipyridine commonly used as a neutral ligand for complexation with metal ions. The molecule is planar with trans-conformation and crystallizes in the monoclinic crystal system.

Biochem/physiol Actions

Metalloprotease inhibitor, high-affinity chelator of iron; may inhibit Fe2+ containing enzymes at 10?8?M.

Safety Profile

Poison by ingestion,subcutaneous, and intraperitoneal routes. Experimentalteratogenic data. Questionable carcinogen withexperimental tumorigenic data. Mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.

Purification Methods

2,2'-Bipyridyl crystallises from hexane, or EtOH, or (after charcoal treatment of a CHCl3 solution) from pet ether. Also, it precipitates from a concentrated solution in EtOH by addition of H2O. Dry it in a vacuum over P2O5. It can be further purified by chromatography on Al2O3 or by sublimation. UV (EtOH): at 280nm (log 4.13). max [Airoldi et al. J Chem Soc, Dalton Trans 1913 1986, Beilstein 23 H 199, 23/8 V 16.]

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View Lastest Price from 2,2'-Bipyridine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-02-24 2,2' Dipyridyl
US $20.00 / KG 1KG 99% 200 tons/ year Speranza Chemical Co., Ltd.
2021-12-01 2, 2′-Dipyridyl
US $9.00 / ASSAYS 1ASSAYS 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-11-30 2,2'-Bipyridine
US $111.00 / KG 25KG 98% 1-10mt Baoji Guokang Bio-Technology Co., Ltd.
  • 2,2'-Bipyridine
  • US $111.00 / KG
  • 98%
  • Baoji Guokang Bio-Technology Co., Ltd.
2,2'-Bipyridine, ACS, 98.0% min. 2,2-Bipyridyl (2,2-Bipyridine) 2,2'-Bipyridyl ReagentPlus(R), >=99% 2,2'-Bipyridyl Vetec(TM) reagent grade, 98% 2,2'-Bipyridine GR for analysis (reagent for iron(II) and molybdenum) ACS 2,2'-Dipyridyl≥ 99.5% (GC) ,’-Dipyridyl 2,2’-bipyridin CI-588 'LGC' (1607) 2,2'-DIPYRIDYL 2,2'-BIPYRIDINE A,A'-DIPYRIDYL ALPHA, ALPHA'-BIPYRIDINE ALPHA, ALPHA'-BIPYRIDYL ALPHA,ALPHA'-DIPYRIDYL α,α’-Bipyridyl 2,2-Dipyridyl (2,2-bipyridine) 2,2-Dipyridyl 99.5+ % for analysis BipyridineBIPYwhiteoffwhitextl 2,2'Bipyridinyl 2,2'-BIPYRIDYL, REDOX INDICATOR 2,2'-DIPYRIDYL, REAGENTPLUS, >=99% 2,2'-BIPYRIDINE PESTANAL 2,2,-Dipyridyl99+% 2, 2- DIPYRIDYL GR 2-2-BIPYRIDYL GR (2,2-Dipyridyl) 2,2'-Bipyridyl,99% 2,2'-BIPYRIDINE, REAG. 2,2'-BIPYRIDINE REAGENT (ACS) 2,2bipyridine, Bipyridine, Alpha, alphabipyridine, Alpha, alphabipyridyl, 2,2bipyridyl, CI-588, Alpha, alphadipyridyl, 2,2dipyridyl 2,2'-Bipyridine,99+%BIPY 2,2''-BIPYRIDINE BIPY 2,2''-DIPYRIDINE / 2,2''-DIPYRIDYL 2.2-BIPHENYL 99% 2,2''-BIPYRIDYL, GR 99+% 2,2'-Bipyridine, 99+% 2,2'-Bipyridine 2,2'-BIPYRIDINE (2,2'-Bipyridyl) 2'-Bipyridine 2,2-Dipyridyl 99+%, White Crystalline Powder, Reagent Grade α,α'-Dipyridyl, 2,2'-Dipyridyl 2,2'-BIPYRIDINE GR FOR ANALYSIS (REAGENT 2,2'-Bipyridine, ACS, 98% AA-DP alpha,alpha’-dwupirydylu alpha,alpha'-Dipyridine 2,2-Bipyridine, Reagent BIPYRIDINE(2,2'-) 2,2'-Bipyridin 2,2'-Dipyridine 2, 2 - al pyridine 2,2′-Bipyridyl,anhydrous, free-flowing 2,6'-Bipyridine 2,2'-Dipyridyl p.a. -Hydroxyphenyl)-2-butanone-d5 Oxime 6-Bromo-2,2' 4-Hydroxymethyl-4'
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