ChemicalBook >> CAS DataBase List >>(+)-Bicuculline

(+)-Bicuculline

CAS No.
485-49-4
Chemical Name:
(+)-Bicuculline
Synonyms
NSC 3219;bicucullin;NSC 32192);Bucuculline;BICUCULLINE;D-BICUCULLINE;(+)-BICUCULINE;(+)-BICUCULLINE;PLUS-BICUCULLINE;(+)-Bicuculline,98%
CBNumber:
CB3418662
Molecular Formula:
C20H17NO6
Molecular Weight:
367.35
MDL Number:
MFCD00005006
MOL File:
485-49-4.mol

(+)-Bicuculline Properties

Melting point 193-197 °C
alpha D25 +130.5° (CHCl3)
Boiling point 497.92°C (rough estimate)
Density 1.3694 (rough estimate)
refractive index 1.5600 (estimate)
storage temp. 2-8°C
solubility Benzene, Chloroform, DMSO, Ethyl Acetate
pka 4.84(at 25℃)
form Off-white to yellow powder.
color Pale Yellow
optical activity [α]20/D +126±6°, c = 1% in chloroform
λmax 325nm(lit.)
Merck 14,1203
BRN 98786
InChIKey IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS DataBase Reference 485-49-4(CAS DataBase Reference)
FDA UNII Y37615DVKC
EPA Substance Registry System Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H401
Precautionary statements  P261-P264-P270-P271-P273-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P403+P233-P405-P501
Hazard Codes  T,N,Xn
Risk Statements  23/24/25-50-36/37/38-20/21/22
Safety Statements  36/37-45-61-36-26
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  LV0909840
10-23
HazardClass  6.1(b)
PackingGroup  III
HS Code  29399990
Toxicity LD50 ipr-mus: 8480 mg/kg CUTOEX 1,199,93

(+)-Bicuculline price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 14340 (+)-Bicuculline ≥97.0% (TLC) 485-49-4 25mg $70.7 2022-05-15 Buy
Sigma-Aldrich 14340 (+)-Bicuculline ≥97.0% (TLC) 485-49-4 100mg $109 2022-05-15 Buy
TCI Chemical B1890 (+)-Bicuculline >98.0%(HPLC)(T) 485-49-4 25mg $52 2022-04-27 Buy
TCI Chemical B1890 (+)-Bicuculline >98.0%(HPLC)(T) 485-49-4 100mg $152 2022-04-27 Buy
Cayman Chemical 11727 Bicuculline ≥98% 485-49-4 50mg $39 2022-04-27 Buy
Product number Packaging Price Buy
14340 25mg $70.7 Buy
14340 100mg $109 Buy
B1890 25mg $52 Buy
B1890 100mg $152 Buy
11727 50mg $39 Buy

(+)-Bicuculline Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.

Uses

GABAa antagonist

Uses

GABAA receptor antagonist.

General Description

Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.

Biological Activity

Classical GABA A antagonist.

Biochem/physiol Actions

(+)-Bicuculline acts as a competitive inhibitor of GABA liganding binding to the receptor.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx.

Purification Methods

It crystallises from CHCl3/MeOH as plates. The crystals melt at 177o, then solidify and re-melt at 193-195o [Manske Canad J Research 21B 13 1943]. It is soluble in CHCl3, *C6H6, EtOAc but sparingly soluble in EtOH, MeOH and Et2O. [Stereochem: Blaha et al. Collect Czech Chem Commun 29 2328 1964, Snatzke et al. Tetrahedron 25 5059 1969, Pharmcol: Curtis et al. Nature 266 1222 1970, Beilstein 27 III/IV 1900].

(+)-Bicuculline Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 279)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29960 58
Chengdu Biopurify Phytochemicals Ltd.
+8618482058008 maggie@biopurify.com China 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254 linda@hubeijusheng.com CHINA 28229 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953 sales@pioneerbiotech.com China 3001 58
Chongqing Chemdad Co., Ltd
+8613650506873 sales@chemdad.com CHINA 37442 58
Shanghai Standard Technology Co., Ltd.
18502101150 ft-sales@nature-standard.com CHINA 1923 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695 info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47501 58

View Lastest Price from (+)-Bicuculline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2022-05-04 (+)-Bicuculline
485-49-4
US $90.00 / kg 1kg 99% 80MT Hebei baicao biology science and technology co., ltd
2021-07-20 (+)-Bicuculline
485-49-4
US $1.00-1.00 / Kg/Bag 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-06-11 (+)-Bicuculline USP/EP/BP
485-49-4
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
  • (+)-Bicuculline
    485-49-4
  • US $90.00 / kg
  • 99%
  • Hebei baicao biology science and technology co., ltd
  • (+)-Bicuculline
    485-49-4
  • US $1.00-1.00 / Kg/Bag
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
5-g)isoquinolin-5-yl)-,(r-(r*,s*))-lo( bicucullin Bucuculline d-Bicuculline/(+)-Bicuculline D-alkali than buttoned Spirit Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one furo(3,4-e)-1,3-benzodioxol-8(6h)-one,6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxo (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one NSC 3219 NSC 32192) (6R)-6-[(5S)-6-Methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one 1,3-Dioxolo[4,5-g]isoquinoline, furo[3,4-e]-1,3-benzodioxol-8(6H)-one deriv. Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g) isoquinolin-5-yl)-, (R-(R*,S*))- (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one (+)-Bicuculline,98% PLUS-BICUCULLINE (+)-BICUCULLINE 1(S),9(R) (r-(r*,s*))-6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-furo(3,4-e)-1,3-benzodioxol-8(6h)-one [R-(R*,S*)]-6-(5,6,7,8-TETRAHYDRO-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL)FURO[3,4-E]-1,3-BENZODIOXOL-8(6H)-ONE (+)-BICUCULINE (+)-BICUCULLINE BICUCULLINE D-BICUCULLINE BICUCULLINE, (+)-(P) (+)-Bicuculline, 99%, a GABAA antagonist (+)-Bicuculline > (R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one (+)-Bicuculline USP/EP/BP (+) bicuculline DISCONTINUED, offer B382500 485-49-4 C20H17NO6 Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Alkaloids Intermediates & Fine Chemicals Pharmaceuticals GABA/Glycine receptor GABA
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