ChemicalBook >> CAS DataBase List >>(+)-Bicuculline
(+)-Bicuculline
- CAS No.
- 485-49-4
- Chemical Name:
- (+)-Bicuculline
- Synonyms
- NSC 3219;bicucullin;NSC 32192);Bucuculline;BICUCULLINE;D-BICUCULLINE;(+)-BICUCULINE;(+)-BICUCULLINE;PLUS-BICUCULLINE;(+)-Bicuculline,98%
- CBNumber:
- CB3418662
- Molecular Formula:
- C20H17NO6
- Molecular Weight:
- 367.35
- MDL Number:
- MFCD00005006
- MOL File:
- 485-49-4.mol
| Melting point | 193-197 °C |
|---|---|
| alpha | D25 +130.5° (CHCl3) |
| Boiling point | 497.92°C (rough estimate) |
| Density | 1.3694 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| storage temp. | 2-8°C |
| solubility | Benzene, Chloroform, DMSO, Ethyl Acetate |
| pka | 4.84(at 25℃) |
| form | Off-white to yellow powder. |
| color | Pale Yellow |
| optical activity | [α]20/D +126±6°, c = 1% in chloroform |
| λmax | 325nm(lit.) |
| Merck | 14,1203 |
| BRN | 98786 |
| InChIKey | IYGYMKDQCDOMRE-ZWKOTPCHSA-N |
| CAS DataBase Reference | 485-49-4(CAS DataBase Reference) |
| FDA UNII | Y37615DVKC |
| EPA Substance Registry System | Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331-H401 |
| Precautionary statements | P261-P264-P270-P271-P273-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P403+P233-P405-P501 |
| Hazard Codes | T,N,Xn |
| Risk Statements | 23/24/25-50-36/37/38-20/21/22 |
| Safety Statements | 36/37-45-61-36-26 |
| RIDADR | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | LV0909840 |
| F | 10-23 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29399990 |
| Toxicity | LD50 ipr-mus: 8480 mg/kg CUTOEX 1,199,93 |
(+)-Bicuculline price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 14340 | (+)-Bicuculline ≥97.0% (TLC) | 485-49-4 | 25mg | $70.7 | 2022-05-15 | Buy |
| Sigma-Aldrich | 14340 | (+)-Bicuculline ≥97.0% (TLC) | 485-49-4 | 100mg | $109 | 2022-05-15 | Buy |
| TCI Chemical | B1890 | (+)-Bicuculline >98.0%(HPLC)(T) | 485-49-4 | 25mg | $52 | 2022-04-27 | Buy |
| TCI Chemical | B1890 | (+)-Bicuculline >98.0%(HPLC)(T) | 485-49-4 | 100mg | $152 | 2022-04-27 | Buy |
| Cayman Chemical | 11727 | Bicuculline ≥98% | 485-49-4 | 50mg | $39 | 2022-04-27 | Buy |
(+)-Bicuculline Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.
Uses
GABAa antagonist
Uses
GABAA receptor antagonist.
General Description
Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.
Biological Activity
Classical GABA A antagonist.
Biochem/physiol Actions
(+)-Bicuculline acts as a competitive inhibitor of GABA liganding binding to the receptor.
Safety Profile
A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx.
Purification Methods
It crystallises from CHCl3/MeOH as plates. The crystals melt at 177o, then solidify and re-melt at 193-195o [Manske Canad J Research 21B 13 1943]. It is soluble in CHCl3, *C6H6, EtOAc but sparingly soluble in EtOH, MeOH and Et2O. [Stereochem: Blaha et al. Collect Czech Chem Commun 29 2328 1964, Snatzke et al. Tetrahedron 25 5059 1969, Pharmcol: Curtis et al. Nature 266 1222 1970, Beilstein 27 III/IV 1900].
(+)-Bicuculline Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 279)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3623 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29960 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618482058008 | maggie@biopurify.com | China | 2712 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 86-18871470254 | linda@hubeijusheng.com | CHINA | 28229 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3001 | 58 |
| Chongqing Chemdad Co., Ltd | +8613650506873 | sales@chemdad.com | CHINA | 37442 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| HENAN BON INDUSTRIAL CO.,LTD | 0371-55170695 | info@hnbon.com | CHINA | 26742 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47501 | 58 |
View Lastest Price from (+)-Bicuculline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-05-04 | (+)-Bicuculline
485-49-4
|
US $90.00 / kg | 1kg | 99% | 80MT | Hebei baicao biology science and technology co., ltd | |
 |
2021-07-20 | (+)-Bicuculline
485-49-4
|
US $1.00-1.00 / Kg/Bag | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-06-11 | (+)-Bicuculline USP/EP/BP
485-49-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- (+)-Bicuculline
485-49-4
- US $90.00 / kg
- 99%
- Hebei baicao biology science and technology co., ltd
-
- (+)-Bicuculline
485-49-4
- US $1.00-1.00 / Kg/Bag
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- (+)-Bicuculline USP/EP/BP
485-49-4
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
485-49-4((+)-Bicuculline)Related Search:
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(-)-BICUCULLINE METHOCHLORIDE,(-)-BICUCULLINE METHOCHLORIDE
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L-Dicendrine
D-Dicentrine
BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H],BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H]
(-)-BICUCULLINE 1(S),9(R) METHBROMIDE,(-)-BICUCULLINE METHOBROMIDE,(-)-BICUCULLINE 1(S),9(R) METHBROMIDE,(-)-BICUCULLINE METHOBROMIDE
(-)-BICUCULLINE METHCHLORIDE, 1(S),9(R),(-)-BICUCULLINE METHCHLORIDE, 1(S),9(R)
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5-g)isoquinolin-5-yl)-,(r-(r*,s*))-lo(
bicucullin
Bucuculline
d-Bicuculline/(+)-Bicuculline
D-alkali than buttoned Spirit
Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-
6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one
furo(3,4-e)-1,3-benzodioxol-8(6h)-one,6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxo
(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one
NSC 3219
NSC 32192)
(6R)-6-[(5S)-6-Methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one
1,3-Dioxolo[4,5-g]isoquinoline, furo[3,4-e]-1,3-benzodioxol-8(6H)-one deriv.
Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g) isoquinolin-5-yl)-, (R-(R*,S*))-
(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one
(+)-Bicuculline,98%
PLUS-BICUCULLINE
(+)-BICUCULLINE 1(S),9(R)
(r-(r*,s*))-6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-furo(3,4-e)-1,3-benzodioxol-8(6h)-one
[R-(R*,S*)]-6-(5,6,7,8-TETRAHYDRO-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL)FURO[3,4-E]-1,3-BENZODIOXOL-8(6H)-ONE
(+)-BICUCULINE
(+)-BICUCULLINE
BICUCULLINE
D-BICUCULLINE
BICUCULLINE, (+)-(P)
(+)-Bicuculline, 99%, a GABAA antagonist
(+)-Bicuculline >
(R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one
(+)-Bicuculline USP/EP/BP
(+) bicuculline
DISCONTINUED, offer B382500
485-49-4
C20H17NO6
Inhibitors
chemical reagent
pharmaceutical intermediate
phytochemical
reference standards from Chinese medicinal herbs (TCM).
standardized herbal extract
Alkaloids
Intermediates & Fine Chemicals
Pharmaceuticals
GABA/Glycine receptor
GABA