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Menatetrenone

CAS No.
863-61-6
Chemical Name:
Menatetrenone
Synonyms
Vitamin K2;MENAQUINONE;e3100;D00100;Glakay;kaytwo;mk(sub4);k2(sub20);Metetrenone;Vitamin MK-4
CBNumber:
CB2471321
Molecular Formula:
C31H40O2
Molecular Weight:
444.65
MDL Number:
MFCD00079646
MOL File:
863-61-6.mol

Menatetrenone Properties

Melting point 350C
Boiling point 494.59°C (rough estimate)
Density 1.0461 (rough estimate)
refractive index 1.5045 (estimate)
Flash point 2℃
storage temp. -20°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
form neat
color Light Yellow to Yellow Oil to Low-Melting
InChIKey DKHGMERMDICWDU-GHDNBGIDSA-N
CAS DataBase Reference 863-61-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 27Y876D139
NCI Drug Dictionary menatetrenone

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H302+H312+H332-H319
Precautionary statements  P210-P280-P305+P351+P338
Safety Statements  22-24/25
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  QL9279500
HS Code  2914699000
Toxicity LD50 intravenous in dog: > 40mL/kg

Menatetrenone price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V9378 Vitamin K2 863-61-6 1g $363 2022-05-15 Buy
Sigma-Aldrich V-031 Vitamin K2 (MK-4) solution 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 863-61-6 1mL $98.1 2022-05-15 Buy
Sigma-Aldrich 47774 Menaquinone (K2) analyticalstandard 863-61-6 100mg $39.5 2022-05-15 Buy
Cayman Chemical 18423 Menaquinone 4 ≥98% 863-61-6 100mg $35 2022-04-27 Buy
Cayman Chemical 18423 Menaquinone 4 ≥98% 863-61-6 1g $277 2022-04-27 Buy
Product number Packaging Price Buy
V9378 1g $363 Buy
V-031 1mL $98.1 Buy
47774 100mg $39.5 Buy
18423 100mg $35 Buy
18423 1g $277 Buy

Menatetrenone Chemical Properties,Uses,Production

Description

Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.

References

https://pubchem.ncbi.nlm.nih.gov/compound/menatetrenone#section=Biomolecular-Interactions-and-Pathways
https://en.wikipedia.org/wiki/Menatetrenone

Chemical Properties

Yellow Crystals

Uses

Vitamin (prothrombogenic)

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis.

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari ety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is k nown as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis.

Definition

ChEBI: A menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration.

General Description

Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.

Biochem/physiol Actions

Menatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities.

66958-54-1
863-61-6
Synthesis of Menatetrenone from Naphthalene, 1,4-dimethoxy-2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl]- (9CI)

Menatetrenone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 189)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 22021 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 fandachem@gmail.com China 9396 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 sales@fine-chemtech.com CHINA 890 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29960 58
Rionlon ( Tianjin ) Pharmaceutical Co., Ltd.
0086-13512289226 yangli@rionlon.com CHINA 28 58
BOC Sciences
631-4854226 inquiry@bocsci.com United States 19527 58
Chongqing Chemdad Co., Ltd
+8613650506873 sales@chemdad.com CHINA 37442 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
021-61999440 contact@trustwe.com CHINA 4766 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19231 58
Hebei Lingding Biological Technology Co., Ltd
+86-19933155420 +86-19933155420 sales1@hbldbiotech.com China 938 58

View Lastest Price from Menatetrenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Menatetrenone
863-61-6
US $289.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-09-29 Menatetrenone
863-61-6
US $0.00 / KG 1KG 98%min 500KGS WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-10 Vitamin K2 Mk4 ;Vitamin K2;Menatetrenone
863-61-6
US $1000.00 / Kg/Bag 1Kg/Bag 98% 2500kg/month XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
  • Menatetrenone
    863-61-6
  • US $289.00 / KG
  • 99%
  • Hebei Lingding Biological Technology Co., Ltd
  • Menatetrenone
    863-61-6
  • US $0.00 / KG
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
MENATETRENONE MENAQUINONE 4 1,4-naphthoquinone,2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoqu 2-methyl-3-trans-tetraprenyl-1,4-naphthoquinone e3100 k2(sub20) menatetranone Menaquinone4, Menatetrenone Menaquinone4, Menatetrenone, VitaminK2 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthoquinone Menaquinone K4 Vitamin MK-4 D00100 Menatetrenone (jp15/inn) Vitamin K2 (tn) menaquinon-4 VITAMIN K2(MENAQUINONE-4)(SH) Vitamin K2(MK-4) Metetrenone Vitamin K2 (MK-4) solution Vitamin K2(20),MK4 0.13% Vitamin K2(20),MK4 1.3% oil Vitamin K2(20),MK4 1.3% powder Vitamin K2(20),MK-4 JP14 powder 2-Methyl-3-geranylgeranyl-1,4-naphthoquinone Glakay Menaquinone 4 (Mixture of cis-trans isoMers) Menatetrenone(11032-49-8) kaytwo menaquinonek(sub4) mk(sub4) vitamink2(sub20) MENAQUINONE (K2) 100MG NEAT VitaminK2(20)0.13%Oil VitaminK2(45)98.0%Min.Powder VitaminK2(20) VitaminK2(20)1.3%Powder VitaminK2(20)98.0%Oil VitaminK2(20)98.0%Powder VitaminK2(20)0.13%Powder VitaminK2(20)1.3%Oil (E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione Vitamin K2(20),MK4 0.13% powder Vitamin K2,MK4,menaquinone, menaquinon-4, menatetrenone, menatetren, menatetrenona, menatetrenonum Phytonadione,(Z) Vitamin K2-Menatetrenone ( MK-4 ) Menatetrenone (MK-4) vitamin K2 Menatetrenone Menatetrenone RS Menaquinone-4 Standard 1,4-Naphthalenedione, 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]- Menatetrenone USP/EP/BP 2-Methyl-3-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)naphthalene-1,4-dione Menatetrenone (Vitamin MK4, E3100) Vitamin K2 (Mk-4) Menatetrenone Menatetrenone,863-61-6
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