Menatetrenone | 863-61-6

Menatetrenone Properties

Melting point	350C
Boiling point	494.59°C (rough estimate)
Density	1.0461 (rough estimate)
refractive index	1.5045 (estimate)
Flash point	2℃
storage temp.	-20°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
form	neat
color	Light Yellow to Yellow Oil to Low-Melting
InChIKey	DKHGMERMDICWDU-GHDNBGIDSA-N
CAS DataBase Reference	863-61-6(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	27Y876D139
NCI Drug Dictionary	menatetrenone

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02,GHS07
Signal word	Danger
Hazard statements	H225-H302+H312+H332-H319
Precautionary statements	P210-P280-P305+P351+P338
Safety Statements	22-24/25
RIDADR	UN 1648 3 / PGII
WGK Germany	3
RTECS	QL9279500
HS Code	2914699000
Toxicity	LD50 intravenous in dog: > 40mL/kg

Menatetrenone price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	V9378	Vitamin K2	863-61-6	1g	$363	2022-05-15	Buy
Sigma-Aldrich	V-031	Vitamin K2 (MK-4) solution 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?	863-61-6	1mL	$98.1	2022-05-15	Buy
Sigma-Aldrich	47774	Menaquinone (K2) analyticalstandard	863-61-6	100mg	$39.5	2022-05-15	Buy
Cayman Chemical	18423	Menaquinone 4 ≥98%	863-61-6	100mg	$35	2022-04-27	Buy
Cayman Chemical	18423	Menaquinone 4 ≥98%	863-61-6	1g	$277	2022-04-27	Buy

Product number	Packaging	Price	Buy
V9378	1g	$363	Buy
V-031	1mL	$98.1	Buy
47774	100mg	$39.5	Buy
18423	100mg	$35	Buy
18423	1g	$277	Buy

Menatetrenone Chemical Properties,Uses,Production

Description

Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.

References

https://pubchem.ncbi.nlm.nih.gov/compound/menatetrenone#section=Biomolecular-Interactions-and-Pathways
https://en.wikipedia.org/wiki/Menatetrenone

Chemical Properties

Yellow Crystals

Uses

Vitamin (prothrombogenic)

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis.

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari ety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is k nown as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis.

Definition

ChEBI: A menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration.

General Description

Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.

Biochem/physiol Actions

Menatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities.

Menatetrenone synthesis

Synthesis of Menatetrenone from Naphthalene, 1,4-dimethoxy-2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl]- (9CI)

Menatetrenone Preparation Products And Raw materials

Raw materials

Preparation Products

Menatetrenone Suppliers

Global( 189)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	22021	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	fandachem@gmail.com	China	9396	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	890	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29960	58
Rionlon ( Tianjin ) Pharmaceutical Co., Ltd.	0086-13512289226	yangli@rionlon.com	CHINA	28	58
BOC Sciences	631-4854226	inquiry@bocsci.com	United States	19527	58
Chongqing Chemdad Co., Ltd	+8613650506873	sales@chemdad.com	CHINA	37442	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	021-61999440	contact@trustwe.com	CHINA	4766	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19231	58
Hebei Lingding Biological Technology Co., Ltd	+86-19933155420 +86-19933155420	sales1@hbldbiotech.com	China	938	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55
career henan chemical co	58
Rionlon ( Tianjin ) Pharmaceutical Co., Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Hebei Lingding Biological Technology Co., Ltd	58

View Lastest Price from Menatetrenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-10-20	Menatetrenone 863-61-6	US $289.00 / KG	1KG	99%	9000kg/per week	Hebei Lingding Biological Technology Co., Ltd
2021-09-29	Menatetrenone 863-61-6	US $0.00 / KG	1KG	98%min	500KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-10	Vitamin K2 Mk4 ;Vitamin K2;Menatetrenone 863-61-6	US $1000.00 / Kg/Bag	1Kg/Bag	98%	2500kg/month	XI'AN TIANGUANGYUAN BIOTECH CO., LTD.

Menatetrenone
863-61-6
US $289.00 / KG
99%
Hebei Lingding Biological Technology Co., Ltd

Menatetrenone
863-61-6
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Vitamin K2 Mk4 ;Vitamin K2;Menatetrenone
863-61-6
US $1000.00 / Kg/Bag
98%
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.

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MENATETRENONE MENAQUINONE 4 1,4-naphthoquinone,2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoqu 2-methyl-3-trans-tetraprenyl-1,4-naphthoquinone e3100 k2(sub20) menatetranone Menaquinone4, Menatetrenone Menaquinone4, Menatetrenone, VitaminK2 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthoquinone Menaquinone K4 Vitamin MK-4 D00100 Menatetrenone (jp15/inn) Vitamin K2 (tn) menaquinon-4 VITAMIN K2(MENAQUINONE-4)(SH) Vitamin K2(MK-4) Metetrenone Vitamin K2 (MK-4) solution Vitamin K2(20),MK4 0.13% Vitamin K2(20),MK4 1.3% oil Vitamin K2(20),MK4 1.3% powder Vitamin K2(20),MK-4 JP14 powder 2-Methyl-3-geranylgeranyl-1,4-naphthoquinone Glakay Menaquinone 4 (Mixture of cis-trans isoMers) Menatetrenone(11032-49-8) kaytwo menaquinonek(sub4) mk(sub4) vitamink2(sub20) MENAQUINONE (K2) 100MG NEAT VitaminK2(20)0.13%Oil VitaminK2(45)98.0%Min.Powder VitaminK2(20) VitaminK2(20)1.3%Powder VitaminK2(20)98.0%Oil VitaminK2(20)98.0%Powder VitaminK2(20)0.13%Powder VitaminK2(20)1.3%Oil (E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione Vitamin K2(20),MK4 0.13% powder Vitamin K2,MK4,menaquinone, menaquinon-4, menatetrenone, menatetren, menatetrenona, menatetrenonum Phytonadione,(Z) Vitamin K2-Menatetrenone ( MK-4 ) Menatetrenone (MK-4) vitamin K2 Menatetrenone Menatetrenone RS Menaquinone-4 Standard 1,4-Naphthalenedione, 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]- Menatetrenone USP/EP/BP 2-Methyl-3-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)naphthalene-1,4-dione Menatetrenone (Vitamin MK4, E3100) Vitamin K2 (Mk-4) Menatetrenone Menatetrenone,863-61-6